Cherokee
Sequoyah finished this in 1821, having worked on it for twelve years without being able to read English or any other script. Within a few years of its adoption the Cherokee Nation had a higher literacy rate than the settlers around it, and by 1828 it had a newspaper.
This is not a cipher. It is a syllabary: each of its eighty-six characters is a whole syllable, not a letter. So it transliterates romanised Cherokee into Sequoyah’s characters rather than enciphering English. Type TSALAGI and you get ᏣᎳᎩ, three syllables and three characters - that is what the Cherokee call themselves. Type hello and you get ᎮlᎶ, because he and lo are syllables and the l in the middle is not.
The one consonant that stands alone is s, Ꮝ, which is why GAWONISGI comes out as five characters: ga-wo-ni-s-gi.
Examples:
Longest match wins, so SA is the single character Ꮜ rather than the standalone s followed by a.